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dc.contributor.authorOKUNROBO, L. O.-
dc.contributor.authorUSIFOH, C. O.-
dc.contributor.authorOKPO, S. O.-
dc.date.accessioned2022-12-01T07:59:36Z-
dc.date.available2022-12-01T07:59:36Z-
dc.date.issued2006-01-07-
dc.identifier.citationOkunrobo, L. O., Usifoh, C. O., & Okpo, S. O. (2006). Reactions of phthalimides with 1-methylethylamine: analgesic and anti-inflammatory properties of resulting carboxamides. Pak. J. Pharm. Sci, 19(1), 28-34.en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/14409-
dc.description.abstractThe reaction of phthalimide derivatives (1a-c) with 1-methylethylamine in dimethylformamide (DMF) at room temperature afforded benzamido-N-prop-2-ynyl-2-(2-methylethyl)-carboxamide (3a), benzamido-N-cyclopentyl-2- (2-methylethyl)-car-boxamide (3b) and benzamido-N-benzyl-2-(2-methylethyl)-carboxamide (3c), respectively. In the carrageenan induced paw oedema test for anti-inflammatory activity, 3a (50 mg/kg) decreased the inflammatory response by 55% after 3 hrs while 3b and 3c exhibited significant reduction in the oedema level. The compounds 3a, 3b and 3c exhibited analgesic activities with 3b producing 76% inhibition. The activities were dose – dependent.en_US
dc.language.isoenen_US
dc.publisherKarachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachien_US
dc.subjectCarboxamidesen_US
dc.subjectsynthesisen_US
dc.subjectanalgesic activityen_US
dc.subjectrat paw oedemaen_US
dc.titleREACTIONS OF PHTHALIMIDES WITH 1-METHYLETHYLAMINE: ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF RESULTING CARBOXAMIDESen_US
dc.typeArticleen_US
Appears in Collections:2006,Part-1

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