REACTIONS OF PHTHALIMIDES WITH 1-METHYLETHYLAMINE: ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF RESULTING CARBOXAMIDES

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Title:	REACTIONS OF PHTHALIMIDES WITH 1-METHYLETHYLAMINE: ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF RESULTING CARBOXAMIDES
Authors:	OKUNROBO, L. O. USIFOH, C. O. OKPO, S. O.
Keywords:	Carboxamides synthesis analgesic activity rat paw oedema
Issue Date:	7-Jan-2006
Publisher:	Karachi: Faculty of Pharmacy & Pharmaceutical Sciences, Karachi
Citation:	Okunrobo, L. O., Usifoh, C. O., & Okpo, S. O. (2006). Reactions of phthalimides with 1-methylethylamine: analgesic and anti-inflammatory properties of resulting carboxamides. Pak. J. Pharm. Sci, 19(1), 28-34.
Abstract:	The reaction of phthalimide derivatives (1a-c) with 1-methylethylamine in dimethylformamide (DMF) at room temperature afforded benzamido-N-prop-2-ynyl-2-(2-methylethyl)-carboxamide (3a), benzamido-N-cyclopentyl-2- (2-methylethyl)-car-boxamide (3b) and benzamido-N-benzyl-2-(2-methylethyl)-carboxamide (3c), respectively. In the carrageenan induced paw oedema test for anti-inflammatory activity, 3a (50 mg/kg) decreased the inflammatory response by 55% after 3 hrs while 3b and 3c exhibited significant reduction in the oedema level. The compounds 3a, 3b and 3c exhibited analgesic activities with 3b producing 76% inhibition. The activities were dose – dependent.
URI:	http://142.54.178.187:9060/xmlui/handle/123456789/14409
ISSN:	1011-601X
Appears in Collections:	2006,Part-1

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