Please use this identifier to cite or link to this item:
http://142.54.178.187:9060/xmlui/handle/123456789/14726| Title: | Pharmacology of atorvastatin on myocardial ischemia-reperfusion in rats and drug effect analysis |
| Authors: | Cao, Bingfeng Bi, Guofeng Wang, Yufeng |
| Keywords: | Atorvastatin myocardial ischemia-reperfusion apoptosis oxidative stress lipid regulating drugs |
| Issue Date: | 20-Sep-2019 |
| Publisher: | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
| Citation: | Cao, B., Bi, G., & Wang, Y. (2019). Pharmacology of atorvastatin on myocardial ischemia-reperfusion in rats and drug effect analysis. Pakistan Journal of Pharmaceutical Sciences, 32. |
| Abstract: | Statins are the most important drugs in the treatment of atherosclerosis. In this paper, the authors analyze the protective effect of atorvastatin on myocardial ischemia-reperfusion in rats and its drug effect. The results showed that the ratio of myocardial infarction area to total ischemia area in atorvastatin group was smaller than that in ischemia reperfusion group (P<0.01). Compared with the ischemia-reperfusion group, the MDA (16.234.05), TNF alpha (41.84 5.61) and MPO (17.542.81) were decreased in atorvastatin group. The results showed that atorvastatin could improve many hemodynamic indexes including SBP, DBP, LVSP, LVEDP and so on. To sum up, atorvastatin can affect infarct size, improve hemodynamics and left ventricular function after myocardial ischemia-reperfusion injury. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/14726 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue 5 (Special) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 14-7431-SP.htm | 141 B | HTML | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.