Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/16395
Title: Anti-inflammatory terpenoids from Cyperus rotundus rhizomes
Authors: Sabrin Ragab Mohamed Ibrahim
Gamal Abdallah Mohamed
Maan Talaat Abdullah Khayat
Mohamed Fathalla Zayed
El-Kholy, Amal Abd-Elmoneim Soliman
Keywords: Cyperus rotundus
cyperaceae
terpenoids
cyperalin a
anti-inflammatory
Issue Date: 1-Jul-2018
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi
Citation: Ibrahim, S. R. M., Mohamed, G. A., Khayat, M. T. A., Zayed, M. F., & El-Kholy, A. A. E. S. (2018). Anti-inflammatory terpenoids from Cyperus rotundus rhizomes. Pakistan journal of pharmaceutical sciences, 31.
Abstract: Phytochemical investigation of the methanolic extract of Cyperus rotundus L. (Cyperaceae) rhizomes afforded a new norterpenoid with an unprecedented carbon skeleton, namely cyperalin A (1) and sugetriol triacetate (2). Their structures were identified by using advanced spectroscopic technique such as UV, IR, 1D (1 H and 13C), 2D (1 H-1 H COSY, HSQC, HMBC, and NOESY) NMR, and HRESIMS as well as comparison with literature data. The isolated compounds were evaluated for their anti-inflammatory activity. Compound 1 displayed the highest inhibitory activity of PGE2, COX-2, and LOX-5 with IC50s 0.22, 1.03, and 1.37 µM, respectively compared to indomethacin (IC50s 0.15, 0.69, and 0.81 µM, respectively). Moreover, 2 demonstrated significant activity with IC50s 0.57 (PGE2), 1.74 (COX-2) and 2.03 (LOX-5) µM.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/16395
ISSN: 1011-601X
Appears in Collections:Issue No.4 (Supplementary)

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