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Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/16526
Title: PHARMACOKINETIC STUDY ABOUT INTERACTION OF NAPROXEN AND ISONIAZID
Authors: MUHAMMAD TAYYAB ANSARI
BASHIR AHMED LOOTHAR
KHAN, QASIM JAHANGIR
Issue Date: 5-Jan-1999
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi
Citation: ANSARI, M. T., LOOTHAR, B. A., & KHAN, Q. J. (1999). Pharmacokinetic study about interaction of Naproxen and Isoniazid. Pakistan Journal of Pharmaceutical Sciences, 12(1), 27-32.
Abstract: Effect of Naproxen (500 mg) was studied on the pharmacokinetic characteristics of Isoniazed (300 mg) in ten healthy human volunteers in a complete cross-over design. A high performance liquid chromatography (HPLC) method was used to analyze serum drug concentrations. Naproxen caused a highly significant (P<0.001) increase in AUC, significant (P<0.05) increase in elimination half life (t1/2) and time for the maximum drug concentration (tmax) while significant (P<0.05) decrease in elimination rate constant (Ke). Insignificant decrease and increase was observed in absorption rate constant (Ka) and maximum drug concentration (Cmax) respectively.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/16526
ISSN: 1011-601X
Appears in Collections:Issue 1

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