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http://142.54.178.187:9060/xmlui/handle/123456789/16526| Title: | PHARMACOKINETIC STUDY ABOUT INTERACTION OF NAPROXEN AND ISONIAZID |
| Authors: | MUHAMMAD TAYYAB ANSARI BASHIR AHMED LOOTHAR KHAN, QASIM JAHANGIR |
| Issue Date: | 5-Jan-1999 |
| Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
| Citation: | ANSARI, M. T., LOOTHAR, B. A., & KHAN, Q. J. (1999). Pharmacokinetic study about interaction of Naproxen and Isoniazid. Pakistan Journal of Pharmaceutical Sciences, 12(1), 27-32. |
| Abstract: | Effect of Naproxen (500 mg) was studied on the pharmacokinetic characteristics of Isoniazed (300 mg) in ten healthy human volunteers in a complete cross-over design. A high performance liquid chromatography (HPLC) method was used to analyze serum drug concentrations. Naproxen caused a highly significant (P<0.001) increase in AUC, significant (P<0.05) increase in elimination half life (t1/2) and time for the maximum drug concentration (tmax) while significant (P<0.05) decrease in elimination rate constant (Ke). Insignificant decrease and increase was observed in absorption rate constant (Ka) and maximum drug concentration (Cmax) respectively. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/16526 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue 1 |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Paper-5.htm | 142 B | HTML | View/Open |
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