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  8. Issue 05
Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/19653
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dc.contributor.authorKHAN, KHALID MOHAMMED-
dc.contributor.authorSUMAYYA SAIED-
dc.contributor.authorMUGHAL, UZMA RASOOL-
dc.contributor.authorMARIUM MUNAWAR-
dc.contributor.authorSAMREEN-
dc.contributor.authorAJMAL KHAN-
dc.contributor.authorSHAHNAZ PERVEEN-
dc.date.accessioned2023-09-19T09:24:09Z-
dc.date.available2023-09-19T09:24:09Z-
dc.date.issued2009-10-20-
dc.identifier.citationKhan, K. M., & Mughal, U. R. (2009). Synthesis, leishmanicidal and enzyme inhibitory activities of quinoline-4-carboxylic acids. Journal of The Chemical Society of Pakistan, 31.en_US
dc.identifier.issn0253-5106-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/19653-
dc.description.abstractA series of quinoline4-carboxylic acids 1-13 wæ synthesized and screened for their leishmanicidal, phosphodiesterase, ß•glucuronidase md urease inhibitory properties. Only compounds 3 and 7 were found to be active against leishmaniasis with ICY) values of 76.26 ± 0.71 and 62.86 ± 0.35 pg/mL, respectively. In phosphodiesterase assay only compound 13 showed maximum percentage inhibition (47.2%) among all the tested compounds. Compound 9 showed maximum percentage inhibition value (47.4%) against ß-glucuronidase enzyme. Compound 13 showed maximum percentage inhibition value i.e. 14.10 % against urease enzyme. The structures of all the synthetic compounds were deduced by spectroscopic techniques, including IH NMR, El-MS, IR, and UV spectroscopy.en_US
dc.description.sponsorshipThe chemical society of Pakistan is an approved society from the PSF.en_US
dc.language.isoenen_US
dc.publisherHEJ Research Institute of Chemistry, University of Karachi, Karachi.en_US
dc.titleSynthesis, Leishmanicidal and Enzyme Inhibitory Activities of Quinoline-4-Carboxylic Acidsen_US
dc.typeArticleen_US
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