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  2. MoST Organizations
  3. Pakistan Science Foundation
  4. Pakistan Science Foundation
  5. PSF Research Support (Scientific Research Journals)
  6. Journal of the Chemical Society of Pakistan
  7. Volume 31
  8. Issue 05
Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/19653
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dc.contributor.authorKHAN, KHALID MOHAMMED-
dc.contributor.authorSUMAYYA SAIED-
dc.contributor.authorMUGHAL, UZMA RASOOL-
dc.contributor.authorMARIUM MUNAWAR-
dc.contributor.authorSAMREEN-
dc.contributor.authorAJMAL KHAN-
dc.contributor.authorSHAHNAZ PERVEEN-
dc.date.accessioned2023-09-19T09:24:09Z-
dc.date.available2023-09-19T09:24:09Z-
dc.date.issued2009-10-20-
dc.identifier.citationKhan, K. M., & Mughal, U. R. (2009). Synthesis, leishmanicidal and enzyme inhibitory activities of quinoline-4-carboxylic acids. Journal of The Chemical Society of Pakistan, 31.en_US
dc.identifier.issn0253-5106-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/19653-
dc.description.abstractA series of quinoline4-carboxylic acids 1-13 wæ synthesized and screened for their leishmanicidal, phosphodiesterase, ß•glucuronidase md urease inhibitory properties. Only compounds 3 and 7 were found to be active against leishmaniasis with ICY) values of 76.26 ± 0.71 and 62.86 ± 0.35 pg/mL, respectively. In phosphodiesterase assay only compound 13 showed maximum percentage inhibition (47.2%) among all the tested compounds. Compound 9 showed maximum percentage inhibition value (47.4%) against ß-glucuronidase enzyme. Compound 13 showed maximum percentage inhibition value i.e. 14.10 % against urease enzyme. The structures of all the synthetic compounds were deduced by spectroscopic techniques, including IH NMR, El-MS, IR, and UV spectroscopy.en_US
dc.description.sponsorshipThe chemical society of Pakistan is an approved society from the PSF.en_US
dc.language.isoenen_US
dc.publisherHEJ Research Institute of Chemistry, University of Karachi, Karachi.en_US
dc.titleSynthesis, Leishmanicidal and Enzyme Inhibitory Activities of Quinoline-4-Carboxylic Acidsen_US
dc.typeArticleen_US
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