Synthesis, Leishmanicidal and Enzyme Inhibitory Activities of Quinoline-4-Carboxylic Acids

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Title:	Synthesis, Leishmanicidal and Enzyme Inhibitory Activities of Quinoline-4-Carboxylic Acids
Authors:	KHAN, KHALID MOHAMMED SUMAYYA SAIED MUGHAL, UZMA RASOOL MARIUM MUNAWAR SAMREEN AJMAL KHAN SHAHNAZ PERVEEN
Issue Date:	20-Oct-2009
Publisher:	HEJ Research Institute of Chemistry, University of Karachi, Karachi.
Citation:	Khan, K. M., & Mughal, U. R. (2009). Synthesis, leishmanicidal and enzyme inhibitory activities of quinoline-4-carboxylic acids. Journal of The Chemical Society of Pakistan, 31.
Abstract:	A series of quinoline4-carboxylic acids 1-13 wæ synthesized and screened for their leishmanicidal, phosphodiesterase, ß•glucuronidase md urease inhibitory properties. Only compounds 3 and 7 were found to be active against leishmaniasis with ICY) values of 76.26 ± 0.71 and 62.86 ± 0.35 pg/mL, respectively. In phosphodiesterase assay only compound 13 showed maximum percentage inhibition (47.2%) among all the tested compounds. Compound 9 showed maximum percentage inhibition value (47.4%) against ß-glucuronidase enzyme. Compound 13 showed maximum percentage inhibition value i.e. 14.10 % against urease enzyme. The structures of all the synthetic compounds were deduced by spectroscopic techniques, including IH NMR, El-MS, IR, and UV spectroscopy.
URI:	http://142.54.178.187:9060/xmlui/handle/123456789/19653
ISSN:	0253-5106
Appears in Collections:	Issue 05

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