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http://142.54.178.187:9060/xmlui/handle/123456789/19764| Title: | Antileishmanial Steroidal Alkaloids from Roots of Sarcococca coriacea |
| Authors: | MUHAMMAD IQBAL, CHOUDHARY ACHYUT ADHIKARI SAMREEN ATTA-UR-RAHMAN |
| Issue Date: | 20-Dec-2010 |
| Publisher: | HEJ Research Institute of Chemistry, University of Karachi, Karachi. |
| Citation: | Choudhary, M. I., Adhikari, A., & Rahman, A. (2010). Antileishmanial steroidal alkaloids from roots of Sarcococca coriacea. J Chem Soc Pak, 32, 799-802. |
| Abstract: | Bio-assay guided isolation of secondary metabolites from the plant Sarcococca coriacea (Hook. f.) yielded two steroidal alkaloids, alkaloid C (1) and iso-N-formylchonemorphine (2). The structures of compounds were identified by different spectroscopic techniques. Compounds 1 and 2 showed significant anti-leishmanial activities IC₅₀ = 13.20 ± 0.05 µM and 24.76 ± 0.01 µM, respectively, in comparison with standard drugs pentamidine IC₅₀ = 8.58 ± 0.04 µM and amphotericin B IC₅₀ = 0.31 ± 0.05 µM. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/19764 |
| ISSN: | 0253-5106 |
| Appears in Collections: | Issue 06 |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| ViewByVolume.aspx?v=16&i=VOLUME%2032,%20NO6,%20DEC%202010.htm | 148 B | HTML | View/Open |
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