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  8. Issue 02
Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/19894
Title: Vinblastine: A Review
Authors: INAM-UL.-HAQUE
HINA SARA
Issue Date: 19-Apr-2010
Publisher: HEJ Research Institute of Chemistry, University of Karachi, Karachi.
Citation: Kumar, A. S. H. U. T. O. S. H. (2016). Vincristine and vinblastine: a review. IJMPS, 6, 23-30.
Abstract: Vinblastine sulfate extracted from leaves of Catharanthus roseus is widely used as an anti-cancer drug. Chemically vinblastine is one of the Vinca alkaloids that inhibit the polymerization of tubulin, resulting in the disappearance of the microtubular spindle, and as a consequence they cause the arrest of cell division in their metaphase. There is limited information in the literature on the metabolism of vinblastine. 4-Deacetylvinblastine has been reported to be a urinary metabolite of vinblastine in dog and in humans. Determination and detection of vinblastine sulfate and its metabolites, by different methods, in biological samples is reviewed from 1972 to 2009.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/19894
ISSN: 0253-5106
Appears in Collections:Issue 02

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