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http://142.54.178.187:9060/xmlui/handle/123456789/20015| Title: | Vernonione, A New Urease Inhibitory Carvotacetone Derivative from Vernonia cinerascens |
| Authors: | IRSHAD AHMAD BASHIR AHMAD CHAUDHARY MUHAMMAD ASHRAF MUHAMMAD UZAIR KHALID HUSSAIN JANBAZ |
| Issue Date: | 20-Jun-2012 |
| Publisher: | HEJ Research Institute of Chemistry, University of Karachi, Karachi. |
| Citation: | Ahmad, I., Chaudhary, B. A., Ashraf, M., Uzair, M., & Janbaz, K. H. (2012). Vernonione, a new urease inhibitory carvotacetone derivative from Vernonia cinerascens. Journal of the Chemical Society of Pakistan, 34(3). |
| Abstract: | Vernonione, a new 7-deoxycarvotacetone derivative 1, together with three known sesquiterpene lactones; vernolide A, C (2,3) and potamopholide (4) has been isolated from the methanolic extract of the roots of Vernonia cinerascens. The structure 3β-acetoxy-5α-angeloyloxy7-deoxycarvotacetone was established by using UV, IR, ¹H and ¹³C-NMR spectra (DEPT), 2D-NMR analyses (COSY, HMQC and HMBC experiments) in combination with HRFAB-MS, HREI-MS experiments and in comparison with literature data of related compounds. Compound 1 showed inhibitory potential against enzyme urease in concentration dependant fashion with IC₅₀ value 227.6 µmol. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/20015 |
| ISSN: | 0253-5106 |
| Appears in Collections: | Issue 03 |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| ViewByVolume.aspx?v=176&i=VOLUME%2034,%20NO3,%20JUN%202012.htm | 149 B | HTML | View/Open |
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