Vernonione, A New Urease Inhibitory Carvotacetone Derivative from Vernonia cinerascens

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Title:	Vernonione, A New Urease Inhibitory Carvotacetone Derivative from Vernonia cinerascens
Authors:	IRSHAD AHMAD BASHIR AHMAD CHAUDHARY MUHAMMAD ASHRAF MUHAMMAD UZAIR KHALID HUSSAIN JANBAZ
Issue Date:	20-Jun-2012
Publisher:	HEJ Research Institute of Chemistry, University of Karachi, Karachi.
Citation:	Ahmad, I., Chaudhary, B. A., Ashraf, M., Uzair, M., & Janbaz, K. H. (2012). Vernonione, a new urease inhibitory carvotacetone derivative from Vernonia cinerascens. Journal of the Chemical Society of Pakistan, 34(3).
Abstract:	Vernonione, a new 7-deoxycarvotacetone derivative 1, together with three known sesquiterpene lactones; vernolide A, C (2,3) and potamopholide (4) has been isolated from the methanolic extract of the roots of Vernonia cinerascens. The structure 3β-acetoxy-5α-angeloyloxy7-deoxycarvotacetone was established by using UV, IR, ¹H and ¹³C-NMR spectra (DEPT), 2D-NMR analyses (COSY, HMQC and HMBC experiments) in combination with HRFAB-MS, HREI-MS experiments and in comparison with literature data of related compounds. Compound 1 showed inhibitory potential against enzyme urease in concentration dependant fashion with IC₅₀ value 227.6 µmol.
URI:	http://142.54.178.187:9060/xmlui/handle/123456789/20015
ISSN:	0253-5106
Appears in Collections:	Issue 03

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