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http://142.54.178.187:9060/xmlui/handle/123456789/20030| Title: | Development and Validation of Spectrophotometric Method for the Determination of Nimesulide in Bulk and Tablet Dosage Forms by Biuret Reagent Method |
| Authors: | MUHAMMAD KHALID BHATTI MUHAMMAD MUNAWAR HAYAT RUBIA NASIR FAIZ-UL-HASSAN NASIM MUHAMMAD ASHRAF BUSHRA HUSSAIN IRSHAD AHMAD |
| Keywords: | Biuret reagent Cycloogygenase Nimesulide Spectrophotometry Tablet dosage form. |
| Issue Date: | 20-Jun-2012 |
| Publisher: | HEJ Research Institute of Chemistry, University of Karachi, Karachi. |
| Citation: | Bhatti, M. K., Hayat, M. M., Nasir, R., Ashraf, M., Hussain, B., & Ahmad, I. (2012). Development and validation of spectrophotometric method for the determination of nimesulide in bulk and tablet dosage forms by biuret reagent method. Journal of the Chemical Society of Pakistan, 34(3). |
| Abstract: | The purpose of the study was to develop a method for the determination of Nimesulide using visible spectrophotometry. It is based on the reaction of Nimesulide with biuret reagent, which forms a greenish coloured complex. The formed complex exhibited maximum absorption at 400 nm. The limit of detection of Nimesulide was 2.5 µg mL ⁻¹ and the limit of quantification was 5.0 µg mL⁻¹. The developed method has acceptable accuracy (97-101%) and correlation coefficient (< 3%). The method was successfully applied on three different tablet dosage brands available in Pakistani market and statistical data shows that results are reliable and reproducible. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/20030 |
| ISSN: | 0253-5106 |
| Appears in Collections: | Issue 03 |
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