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http://142.54.178.187:9060/xmlui/handle/123456789/982| Title: | SOLUBILITY OF OXALATE AND ITS ASSOCIATION WITH METAL IONS ASSESSED BY A SIMULATED IN VITRODIGESTION MODEL |
| Authors: | Beenish Israr* Richard Andrew Frazier Micheal Hodson Gordon |
| Keywords: | Organic acid calcium regulation gastric pH soluble oxalate soluble salts metal detoxification Agriculture Science |
| Issue Date: | 2019 |
| Publisher: | Pakistan Journal of Agricultural Sciences, Faisalabad, |
| Abstract: | Bioavailabilityofoxalateishighlyinfluencedbythepresenceofmetalcationsinthegastrointestinaltractasaresultofthedifferentsolubilityofoxalatesalts.BioavailabilityisfurtherinfluencedbypHeffectsonoxalatesolubilityatvariousstagesofdigestion,particularlyatgastricpHatwhichinsolubleoxalatehasbeenfoundtosolubilize.TheaimofthepresentstudywastoassesstheeffectofgastrointestinalpHanddifferentmetalionsontherelativesolubilityofoxalateaftertreatmentwithrelevantgastricandintestinalenzymesinsimulatedgastrointestinaldigestionconditions.Wholebrancerealsandbeanswereusedastestsamples.Oxalatesolubilityincreasedalongwithreproduciblerecoverysuchas97±4atgastricpH-2comparedtohigherpH.Highamountofsolubleoxalate(32±1.2)wasfoundinwheatbranaftersimulatedinvitrodigestionundergastricconditionsascomparedtointestinalconditionsi.e.11±0.5.Theavailabilityofcalciumforabsorptionwasfoundtobeverylowcomparedtothatofmagnesiumandpotassiumi.e.,15±0.3,13±0.5to10±0.42and4±1inwheatbransampleatgastricandintestinalconditionssimultaneously.Theformationofacomplexbetweencalciumandoxalatereducedsolubilityandhencemadecalciumlessavailableforabsorption.Presenceofmetalsandoxalatenotonlyreducesoxalateavailability,butitalsoreducesavailabilityofmetalcations |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/982 |
| Appears in Collections: | Agriculture Thesis |
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